RESUMO
One hundred and three consecutive cases of breast cancer in Trinidadian women were evaluated for steroid receptor status and c-erbB-2 receptor along with conventional parameters including age, ethnicity, tumour size, histological type and grade, and lymph node status: The molecular markers were studied by immunohistochemistry (IHC) on paraffin sections. Tumour size > 2 cm was seen in 60% of the cases. Oestrogen receptor (ER), progesterone receptor (PR) and c-erbB-2 showed 54%, 46% and 63% positivity, respectively. There was no correlation between c-erbB-2 and steroid receptors. Forty-one per cent of cases showed double negativity for steroid receptors (ER-/PR-). No correlation was found between the markers and conventional parameters except for a negative correlation with the tumour grade. The high percentage of c-erbB-2 positivity and the high proportion of steroid receptor negativity suggest a need for studies on adjuvant therapy. Integration of selected markers with conventional parameters could help define subgroups for treatment and prognosis.
Assuntos
Neoplasias da Mama/química , Carcinoma Intraductal não Infiltrante/química , Receptor ErbB-2/análise , Receptores de Estrogênio/análise , Receptores de Progesterona/análise , Adulto , Idoso , Biomarcadores Tumorais/análise , Neoplasias da Mama/genética , Neoplasias da Mama/patologia , Carcinoma Ductal de Mama/química , Carcinoma Ductal de Mama/genética , Carcinoma Ductal de Mama/patologia , Carcinoma Intraductal não Infiltrante/genética , Carcinoma Intraductal não Infiltrante/patologia , Feminino , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Trinidad e Tobago/epidemiologiaRESUMO
One hundred and three consecutive cases of breast cancer in Trinidadian women were evaluated for steriod receptor status and c-erB-2 receptor along with conventional parameters including age, ethnicity, tumour size, histological type and grade, and lymph node status: The molecular markers were studied by immunohistochemistry (IHC) on paraffin sections. Tumour size > 2 cm was seen in 60 percent of the cases. Oestrogen receptor (ER), progestrone receptor (PR) and c-erbB-2 showed 54 percent, 46 percent, and 63 percent positivity, respectively. There was no correlation between c-erbB-2 and steroid receptors. Forty-one percent of cases showed double negativity for steriod receptors (ER-/PR-). No correlation was found between the markers and conventional parameters except for a negative correlation with the tumour grade. The high percentage of c-erbB-2 positivity and the high propotion of steriod receptor negativity suggest a need for studies on adjuvant therapy. Integration of selected markers with conventional parameters could help define sub-groups for treatment and pragnosis (AU)
Assuntos
Adulto , Pessoa de Meia-Idade , Idoso , Feminino , Humanos , Neoplasias da Mama/patologia , Receptores de Estrogênio/análise , Receptores de Progesterona/análise , Receptores de Esteroides/análise , Receptor ErbB-2/diagnóstico , Trinidad e Tobago/etnologia , Imuno-Histoquímica/estatística & dados numéricos , Parafina/diagnóstico , Estudos de Casos e Controles , Biomarcadores Tumorais , Biomarcadores/análiseRESUMO
One hundred and three consecutive cases of breast cancer in Trinidadian women were evaluated for steroid receptor status and c-erbB-2 receptor along with conventional parameters including age, ethnicity, tumour size, histological type and grade, and lymph node status: The molecular markers were studied by immunohistochemistry (IHC) on paraffin sections. Tumour size > 2 cm was seen in 60 of the cases. Oestrogen receptor (ER), progesterone receptor (PR) and c-erbB-2 showed 54, 46 and 63 positivity, respectively. There was no correlation between c-erbB-2 and steroid receptors. Forty-one per cent of cases showed double negativity for steroid receptors (ER-/PR-). No correlation was found between the markers and conventional parameters except for a negative correlation with the tumour grade. The high percentage of c-erbB-2 positivity and the high proportion of steroid receptor negativity suggest a need for studies on adjuvant therapy. Integration of selected markers with conventional parameters could help define subgroups for treatment and prognosis.
Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Neoplasias da Mama , Receptores de Progesterona , Receptor ErbB-2 , Carcinoma Intraductal não Infiltrante/química , Receptores de Estrogênio/análise , Trinidad e Tobago , Neoplasias da Mama , Imuno-Histoquímica , Carcinoma Ductal de Mama , Carcinoma Intraductal não Infiltrante/genética , Carcinoma Intraductal não Infiltrante/patologia , Biomarcadores Tumorais/análiseRESUMO
One hundred and three consecutive cases of breast cancer in Trinidadian women were evaluated for steroid receptor status and c-erb-B2 receptor along with clinicopathological data including age, race, tumour size, histological type and grade and lymph node status. The molecular markers were studied by immunohistochemistry (IHC) on parrafin sections. Tumour size of > 2cm was seen in 60 percent of the cases. Oestrogen receptor (ER), progesterone receptor (PR) and c-erb-B2 showed 54 percent, 46 percent and 63 percent positivity, respectively. There was no correlation between c-erb-B2 and steroid receptors. Forty-one percent (41 percent) of cases showed double negativity for steroid receptors (ER-/PR-). No correlation was found between the markers and clinicopathological data except for negative correlation with the tumour grade. The high percentage of c-erb-B2 positivity and the high proportion of steroid receptor negativity suggest a need for studies on adjuvant therapy. Integration of selected markers with conventional parameters could help define subgroups for treatment and prognosis. (AU)
